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And Golden, S. H. (2004). Meta-analysis: Glycosylated hemoglobin and cardiovascular disease in diabetes mellitus, Annals of Internal Medicine, 141, 421–431. 26. Simon, R. (2001). , M. K. Gospodarowicz, D. E. Henson, R. V. P. Hutter, B. O’Sullivan, L. H. Sobin, and C. Wittekind), pp. 49–56, Wiley-Liss, New York. 27. , and Altman, D. G. (1994). Statistical aspects of prognostic factor studies in oncology, British Journal of Cancer, 69, 979–985. 28. Stewart, L. , and Clarke, M. J. (1995). Practical methodology of metaanalyses (overviews) using updated individual patient data.
Although it was clear that the IPD approach was desirable, we aimed to assess whether such a study was feasible. 2 Systematic Review Based on Individual Patient Data The broad reasons in favour of IPD reviews together with the principal beneﬁts over reviews based on published studies are summarised by Riley et al. (2006). Key advantages include being able to analyse the data in a consistent manner and reducing (if not eliminating) the eﬀect of publication bias. Noteworthy disadvantages are the considerable resources needed to carry out such a review and diﬃculties encountered in obtaining the data sets, particularly if they were created a long time ago.
Abrams, K. , Sutton, A. , Lambert, P. , Jones, D. , and Burchill, S. A. (2003). Reporting of prognostic markers: Current problems and development of guidelines for evidence-based practice in the future, British Journal of Cancer, 88, 1191–1198. 21. Riley, R. , Abrams, K. , Lambert, P. , Sutton, A. , and Altman, D. G. (2006). Where next for evidence synthesis of prognostic marker studies? Improving the quality and reporting of primary studies to facilitate clinically relevant evidence-based results, in this volume.